Application Detail

Description of Medical Service

Tisagenlecleucel is an autologous, murine anti-CD19 Chimeric Antigen Receptor T cell (CAR-T) therapeutic process, involving harvesting, modifying, expanding and re-infusing a patient's own immune T-cells, to target and destroy certain cancerous cells.

Description of Medical Condition

Diffuse Large B-Cell Lymphoma (DLBCL) is an aggressive and common subtype of Non-Hodgkin Lymphoma (NHL).

Reason for Application

Re-submission

Medical Service Type

Hybrid health technology

Previous Application Number

1519

Associated Documentation

Application Form

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Consultation Survey

Feedback and comments are welcome at any stage during the MSAC process. Please provide comments on Application 1519.1 via a maximum of two A4 pages to HTA@health.gov.au (making sure that you type the application number at the start of your comments and in the subject heading of your email).

PICO Confirmation

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Assessment Report

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Public Summary Document

Public Summary Document (PDF 1293 KB)
Public Summary Document (Word 240 KB)

Meetings for this Application

PASC

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ESC

13 June 2019

MSAC

1-2 August 2019
28-29 November 2019

MSAC stakeholder meeting for CAR-T cell therapy for relapsed or refractory Diffuse Large B Cell Lymphoma, Primary Mediastinal B-cell Lymphoma and Follicular Lymphoma

The Medical Services Advisory Committee (MSAC) held a stakeholder meeting on 12 November 2019 on CAR-T cell therapy for relapsed or refractory Diffuse Large B Cell Lymphoma (DLBCL), Primary Mediastinal B-cell Lymphoma (PMBCL), and Follicular Lymphoma (FL).

The purpose of the meeting was to allow MSAC to seek advice on patient eligibility for treatment and other aspects of patient management, in light of the recent MSAC consideration of Kymriah® (tisagenlecleucel, sponsored by Novartis Australia) and the future MSAC consideration of Yescarta® (axicabtagene ciloleucel, sponsored by Gilead Sciences).

MSAC invited treating clinicians, consumers, and representatives of Novartis and Gilead and the Commonwealth and State/Territory health departments to attend the meeting.

MSAC Stakeholder Meeting Outcome
Final Stakeholder Meeting Outcome Statement (PDF 585 KB)
Final Stakeholder Meeting Outcome Statement (Word 56 KB)