Description of Medical ServiceGermline BRCA mutation testing to determine eligibility for talazoparib treatment in patients with locally advanced or metastatic HER2-negative breast cancer (either hormone receptor positive or triple negative).
Description of Medical ConditionBreast cancer is a major health burden worldwide, including in Australia, where over 16,500 new cases were diagnosed in 2014. In 2018, it is estimated that 18,235 new cases of breast cancer will be diagnosed in Australia (148 males and 18,087 females).
Breast cancer is multifactorial and thought to result from interactions between a number of different environmental, lifestyle, hormonal and genetic factors, including a family history of breast cancer. “Hereditary” or “familial breast cancer” breast cancer suggests that there is a genetic predisposition to breast cancer associated with a particular gene or set of genes, within family groups. Within this group of high risk genes are mutations in the key tumour suppressor genes - the BReast CAncer susceptibility genes 1 or 2 (BRCA1/2). Such mutations may be inherited (germline) or arise de novo (somatic) as a result of combinatorial genetic and environmental factors.
Specific subgroups of individuals have been identified as having a higher proportion of individuals who carry a BRCA mutation, including those who have been diagnosed with triple negative breast cancer (TNBC), men and those from different ethnic groups, including Black populations and those of Ashkenazi Jewish heritage.
Reason for ApplicationAmendment to MBS item
Medical Service TypeInvestigative
Previous Application Number/sNot applicable
Application FormApplication Form (PDF 1109 KB)
Application Form (Word 123 KB)
Consultation SurveyConsultation Survey (PDF 491 KB)
Consultation Survey (Word 70 KB)