1587 - YESCARTA™ (axicabtagene ciloleucel [KTE-C19]) for the treatment of refractory or relapsed CD19-positive lymphoma

Page last updated: 13 August 2019

Application Detail



Description of Medical Service

Axicabtagene ciloleucel is a Chimeric Antigen Receptor T-cell (CAR-T) therapy which can help patients with relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL), Primary Mediastinal B-cell Lymphoma (PMBCL), and Follicular Lymphoma (FL).

Axicabtagene ciloleucel is a CD19-directed genetically modified autologous T-cell immunotherapy. To prepare axicabtagene ciloleucel, patient’s own T-cells are harvested via a standard leukapheresis procedure and genetically modified ex-vivo by retroviral transduction to express a Chimeric Antigen Receptor (CAR). The anti-CD19 CAR-positive viable T-cells are then expanded and infused back into the patient, where they can recognise and eliminate CD19 expressing target cells.

Description of Medical Condition

Non-Hodgkin Lymphoma (NHL) comprises a heterogeneous group of cancers originating primarily in B lymphocytes (and, to a lesser extent in T lymphocytes, and natural killer cells). The prognosis depends on the histologic type, stage, and treatment, along with other factors including the patient’s age and general health, whether there are certain changes in the genes, the amount of Lactate Dehydrogenase (LDH) in the blood, and whether the lymphoma has been newly diagnosed or has recurred.

Aggressive subtypes of B-cell NHL include DLBCL, PMBCL, and FL that has transformed histologically to DLBCL and also referred to as Transformed Follicular Lymphoma (TFL).

Reason for Application

New non-MBS item

Medical Service Type

Hybrid Health Technology

Previous Application Number

Not Applicable

Associated Documentation

Application Form

Application Form (PDF 1105 KB)
Application Form (Word 243 KB)

Consultation Survey

Consultation Survey (PDF 491 KB)
Consultation Survey (Word 70 KB)

PICO Confirmation


Assessment Report


Public Summary Document


Meetings for this Application