Application Detail
Description of Medical Service
The medical service is for the testing of tumour tissue to determine HRD status. The HRD test involves the next generation sequencing (NGS) of DNA from a biopsy or preserved specimens (archived FFPE block) of tumour tissue. An assay detects how your body repairs double strand breaks in DNA, which is constantly being damaged and repaired. When DNA is repaired, the process is called homologous recombination. HRD positive means your body is unable to effectively repair these double strand breaks in the DNA. HRD can include a number of genes, including BRCA1 and BRCA1 genes.Description of Medical Condition
Ovarian cancer is a diverse disease comprising different subtypes. The majority of ovarian cancers are of epithelial origin, with most classified as high-grade tumours. Early symptoms are often nonspecific, such as pelvic or abdominal discomfort, bloating, difficulty eating or feeling full and urinary urgency or frequency. Most patients are therefore diagnosed at an advanced stage (Stage 3 and 4) when prominent symptoms such as ascites (fluid build-up in spaces within the abdomen) and abdominal masses are evident.Reason for Application
New MBS itemMedical Service Type
Investigative – PBAC codependent applicationPrevious Application Number/s
Not ApplicableAssociated Documentation
Application Form
Application Form (PDF 1659 KB)Application Form (Word 475 KB)
Consultation Survey
Consultation Survey (PDF 659 KB)Consultation Survey (Word 27 KB)
PASC Consultation
Expedited – Bypassing PASC
MSAC Consultation
MSAC consultation input closed Friday, 10 February 2023.
For further information please refer to PASC, ESC, MSAC Key Dates
For further information on the consultation process please refer to MSAC Consultation Process
PICO Confirmation
-Assessment Report
-Public Summary Document
Public Summary Document (PDF 1112 KB)Public Summary Document (Word 639 KB)