1544 - Genome-wide microarray testing for people with multiple myeloma and chronic lymphocytic leukaemia

Page last updated: 01 April 2020

Application Detail



Description of Medical Service

Microarray is a general term used for a number of different complex technologies that are used to study the whole genome for both loss of DNA segments (deletion) and gain of DNA segments (duplication). These deletions and duplications are collectively referred to as copy-number variations. Microarray can detect copy-number variations that are too small to be seen by conventional chromosome analysis.

Extend genome-wide microarray testing (MBS item 73292) to use in one additional population and setting:
• For two specific chronic haematological malignancies, chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM), often as an adjunct or alternative testing method to current investigations. MSAC consideration of the use of this test in this second population is also supported by the Haematology Working Group of the Pathology Clinical Committee (PCC).

Description of Medical Condition

Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disease that produces immunologically immature cells. These cells accumulate in peripheral blood and have a solid component that can be found primarily in lymph nodes and bone marrow. The incidence of the disease increases with age, as does the mortality rate.

Management of CLL is dictated by the stage, presence of symptoms and individual patient preference. Current treatment for CLL ranges from monotherapy to combination therapy with chemotherapy and immunomodulatory agents.

Multiple Myeloma (MM) is cancer of the plasma cells in bone marrow. Widespread growth of the malignant plasma cells in the bone marrow leaves little room for normal blood cells, causing a range of problems including weak bones, anaemia and reduced immunity.

MM is rarely seen in people under 40 years of age. There is not cure but the condition can usually be managed successfully for several years. MM is characterised by a profound genomic heterogeneity that involves both numerical and structural chromosomal rearrangements (Fonseca et al, 2004). The evidence to incorporate the use of chromosome microarrays in CLL and MM has been emerging in the scientiic literature in the last 8 years.

Reason for Application

Amendment to MBS item

Medical Service Type


Previous Application Number

Not Applicable

Associated Documentation

Application Form


Consultation Survey


PICO Confirmation

PICO Confirmation (PDF 1504 KB)
PICO Confirmation (Word 396 KB)

Assessment Report


Public Summary Document

Public Summary Document (PDF 812 KB)
Public Summary Document (Word 466 KB)

Meetings for this Application


6-7 December 2018


10-11 October 2019


28-29 November 2019