1686 –177 Lutetium PSMA i&t for metastatic castrate resistant prostate cancer

Page last updated: 31 October 2022

Application Detail

Description of Medical Service

177Lutetium PSMA i&t is a targeted radionuclide radiotherapy that enters the cancer cell via the PSMA receptor, which is overexpressed in prostate cancer, with expression increasing in metastatic and castrate resistant disease. Therapy is intended for patients with progressive metastatic castrate resistant prostate cancer after the disease has progressed despite chemotherapy. Screening with PSMA Positron Emission Tomography (PET) and FDG PET determines if the patient has an adequate level of PSMA ‘target’ at all sites of measurable disease such that they will be expected to derive significant benefit from the treatment.

Description of Medical Condition

Prostate cancer is one of the commonest cancers in Australia. Castrate-resistant prostate cancer is defined by disease progression despite androgen depletion therapy (reducing the amount of testosterone in the body) and may present as either a continuous rise in serum prostate-specific antigen levels (usually elevated in men with prostate cancer), the progression of pre-existing disease, and/or the appearance of new metastases.

Reason for Application

New MBS item

Medical Service Type

Therapeutic technology

Previous Application Number/s

Not Applicable

Associated Documentation

Application Form

Application Form (PDF 1429 KB)
Application Form (Word 975 KB)

Consultation Survey

Consultation Survey (PDF 688 KB)
Consultation Survey (Word 72 KB)

PASC Consultation
PASC consultation closed

MSAC Consultation
MSAC consultation closed Friday, 10 June 2022.

For further information please refer to PASC, ESC, MSAC Key Dates
For further information on the consultation process please refer to MSAC Consultation Process

PICO Confirmation

PICO Confirmation (PDF 738 KB)
PICO Confirmation (Word 439 KB)

Assessment Report


Public Summary Document

Public Summary Document (PDF 1281 KB)
Public Summary Document (Word 865 KB)

Meetings for this Application


9-10 December 2021


9-10 June 2022


28-29 July 2022